PUBLICATIONS

Lee JSalazar Hernández MAAuen TMucka PLee JOzcan U. PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism. Molecular Metabolism, 2017 Oct 28. pii: S2212-8778(17)30737-8 [Pubmed]

Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, Jedrychowski MP, Ozcan U, Gygi SP, Kamenecka TM, Shulman GI, Schreiber SL, Griffin PR, Puigserver P. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell, 2017 Mar 23;169(1):148-160.e15. [PubMed]

Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Cell, 2016 Nov 3; 167(4): 1052-1066. [PubMed]

Lee J, Liu J, Feng X, Salazar Hernandez MA, Mucka P, Ibi D, Choi J, Ozcan U. Withaferin a is a leptin sensitizer with strong antidiabetic properties in mice. Nature Medicine, 2016 August 1; [PubMed]

Herrema H, Zhou Y, Zhang D, Salazar Hernandez MA, Shulman GI, Ozcan, U. XBP1s is an antilipogenic protein. Journal of Biological Chemistry, 2016 June 20; [PubMed]

Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Treatment of Obesity with Celastrol. Cell, 2015 May 21; 161(5):999-1011. [PubMed]

Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. BRD7 regulates XBP1’s activity and glucose homeostasis through its interaction wit the regulatory subunits of PI3K. Cell Metabolism, 2014 Jul 1;20(1):73-84. [PubMed]

Cakir I, Ozcan U. Mom’s milk molds neural wiring for metabolism. Cell, 2014 Jan 30;156(3):396-7. [PubMed]

Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem, 2014 Jan 17;289(3):1203-11. [PubMed]

Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun, 2014 Jan 10;443(2):689-93. [PubMed]

Ozcan U. Mitofusins: mighty regulators of metabolism. Cell, 2013 Sep 26;155(1):17-8. [PubMed]

Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA. Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and possible defective autophagy in fasting mice. Int J Biochem Cell Biol. 2012 Jun;44(6):905-13. [PubMed]

Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nature Medicine, 2011 Sep 4;17(10):1251-60 [PubMed]

Zhou Y, Lee J, Reno CM, Chung J, Sun C, Park SW, Chung J, Lee J, White MF, Biddinger S, Fisher SJ, Ozcan U. Regulation of Glucose Homeostasis Through XBP1-FoxO1 interaction. Nature Medicine, 2011 Mar;17(3):356-65. [PubMed]

Park S, Zhou Y, Lee J, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. PNAS, 2010 Nov 9;107(45):19320-5. [PubMed]

Park S, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nature Medicine, 2010 Apr;16(4):429. [PubMed]

Ozcan L, Ergin AS, Sarkar S, Lu A, Chung J, Nie D, Myers MG, Jr., Ozcan U. Endoplasmic Reticulum Stress Plays A Central Role in Development of Leptin Resistance. Cell Metabolism, 2009 Jan 7;9(1):35-51. [PubMed]